8DTX

Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV89-22

Summary for 8DTX

• Entry DOI: 10.2210/pdb8dtx/pdb
• Related: 8DTR 8DTT
• Descriptor: COV89-22 heavy chain, COV89-22 light chain, Spike protein S2' stem helix peptide, ... (4 entities in total)
• Functional Keywords: sars-cov-2, coronavirus, antibody, stem helix, neutralizing antibody, covid-19, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 99250.98

Authors

Lin, T.H.,Lee, C.C.D.,Wilson, I.A. (deposition date: 2022-07-26, release date: 2022-11-23, Last modification date: 2023-10-25)

• Primary citation: Dacon, C.,Peng, L.,Lin, T.H.,Tucker, C.,Lee, C.D.,Cong, Y.,Wang, L.,Purser, L.,Cooper, A.J.R.,Williams, J.K.,Pyo, C.W.,Yuan, M.,Kosik, I.,Hu, Z.,Zhao, M.,Mohan, D.,Peterson, M.,Skinner, J.,Dixit, S.,Kollins, E.,Huzella, L.,Perry, D.,Byrum, R.,Lembirik, S.,Murphy, M.,Zhang, Y.,Yang, E.S.,Chen, M.,Leung, K.,Weinberg, R.S.,Pegu, A.,Geraghty, D.E.,Davidson, E.,Doranz, B.J.,Douagi, I.,Moir, S.,Yewdell, J.W.,Schmaljohn, C.,Crompton, P.D.,Mascola, J.R.,Holbrook, M.R.,Nemazee, D.,Wilson, I.A.,Tan, J.; Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.; Cell Host Microbe, 31:97-, 2023; PubMed: 36347257; DOI: 10.1016/j.chom.2022.10.010

Experimental method

X-RAY DIFFRACTION (1.6 Å)