8DTO

Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer

8DTO の概要

• エントリーDOI: 10.2210/pdb8dto/pdb
• EMDBエントリー: 27706
• 分子名称: CH848.3.D0949.10.17chim.6R.DS.SOSIP.664_N133D_N138T gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: hiv-1 envelope, vaccine-induced antibody, broadly neutralizing antibody, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 317743.39

構造登録者

Stalls, V.,Acharya, P. (登録日: 2022-07-26, 公開日: 2023-04-19, 最終更新日: 2024-05-22)

• 主引用文献: Wiehe, K.,Saunders, K.O.,Stalls, V.,Cain, D.W.,Venkatayogi, S.,Martin Beem, J.S.,Berry, M.,Evangelous, T.,Henderson, R.,Hora, B.,Xia, S.M.,Jiang, C.,Newman, A.,Bowman, C.,Lu, X.,Bryan, M.E.,Bal, J.,Sanzone, A.,Chen, H.,Eaton, A.,Tomai, M.A.,Fox, C.B.,Tam, Y.K.,Barbosa, C.,Bonsignori, M.,Muramatsu, H.,Alam, S.M.,Montefiori, D.C.,Williams, W.B.,Pardi, N.,Tian, M.,Weissman, D.,Alt, F.W.,Acharya, P.,Haynes, B.F.; Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.; Cell Host Microbe, 32:693-709.e7, 2024; PubMed: 38670093; DOI: 10.1016/j.chom.2024.04.006

実験手法

ELECTRON MICROSCOPY (3.57 Å)