8DSM

Human NAMPT in complex with inhibitor ZN-4-3

Summary for 8DSM

• Entry DOI: 10.2210/pdb8dsm/pdb
• Related: 8DSC 8DSD 8DSE 8DSH
• Descriptor: Nicotinamide phosphoribosyltransferase, (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: nad biosynthesis enzyme:activator complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 230062.18

Authors

Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. (deposition date: 2022-07-22, release date: 2023-08-02, Last modification date: 2024-05-22)

• Primary citation: Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R.; A structural mechanism for positive allosteric modulation of nicotinamide phosphoribosyltransferase to elevate cellular NAD+; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)