8DSM
Human NAMPT in complex with inhibitor ZN-4-3
Summary for 8DSM
Entry DOI | 10.2210/pdb8dsm/pdb |
Related | 8DSC 8DSD 8DSE 8DSH |
Descriptor | Nicotinamide phosphoribosyltransferase, (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | nad biosynthesis enzyme:activator complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 230062.18 |
Authors | Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. (deposition date: 2022-07-22, release date: 2023-08-02, Last modification date: 2024-05-22) |
Primary citation | Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. A structural mechanism for positive allosteric modulation of nicotinamide phosphoribosyltransferase to elevate cellular NAD+ To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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