8DSH

Human NAMPT in complex with quercitrin and AMPcP

Summary for 8DSH

Entry DOI	10.2210/pdb8dsh/pdb
Related	8DSC 8DSD 8DSE
Descriptor	Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, ... (4 entities in total)
Functional Keywords	nad biosynthesis enzyme:activator complex, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	115079.37
Authors	Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. (deposition date: 2022-07-22, release date: 2023-03-08, Last modification date: 2023-10-25)
Primary citation	Ratia, K.M.,Shen, Z.,Gordon-Blake, J.,Lee, H.,Laham, M.S.,Krider, I.S.,Christie, N.,Ackerman-Berrier, M.,Penton, C.,Knowles, N.G.,Musku, S.R.,Fu, J.,Velma, G.R.,Xiong, R.,Thatcher, G.R.J. Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62:923-933, 2023 Cited by PubMed: 36746631 DOI: 10.1021/acs.biochem.2c00655 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation