8DSE
Human NAMPT in complex with substrate NAM and activator quercitrin
Summary for 8DSE
Entry DOI | 10.2210/pdb8dse/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, NICOTINAMIDE, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | nad biosynthesis enzyme:activator complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 114769.46 |
Authors | Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. (deposition date: 2022-07-22, release date: 2023-03-08, Last modification date: 2023-10-25) |
Primary citation | Ratia, K.M.,Shen, Z.,Gordon-Blake, J.,Lee, H.,Laham, M.S.,Krider, I.S.,Christie, N.,Ackerman-Berrier, M.,Penton, C.,Knowles, N.G.,Musku, S.R.,Fu, J.,Velma, G.R.,Xiong, R.,Thatcher, G.R.J. Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62:923-933, 2023 Cited by PubMed: 36746631DOI: 10.1021/acs.biochem.2c00655 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.428 Å) |
Structure validation
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