8DSC

Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R

8DSC の概要

• エントリーDOI: 10.2210/pdb8dsc/pdb
• 分子名称: Nicotinamide phosphoribosyltransferase, NICOTINAMIDE, PHOSPHATE ION, ... (8 entities in total)
• 機能のキーワード: nad biosynthesis enzyme:activator complex, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115117.19

構造登録者

Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. (登録日: 2022-07-22, 公開日: 2023-03-08, 最終更新日: 2023-10-25)

• 主引用文献: Ratia, K.M.,Shen, Z.,Gordon-Blake, J.,Lee, H.,Laham, M.S.,Krider, I.S.,Christie, N.,Ackerman-Berrier, M.,Penton, C.,Knowles, N.G.,Musku, S.R.,Fu, J.,Velma, G.R.,Xiong, R.,Thatcher, G.R.J.; Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.; Biochemistry, 62:923-933, 2023; PubMed: 36746631; DOI: 10.1021/acs.biochem.2c00655

実験手法

X-RAY DIFFRACTION (1.321 Å)