8DRV

Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp8-nsp9 (C8) cut site sequence

8DRV の概要

• エントリーDOI: 10.2210/pdb8drv/pdb
• 分子名称: Fusion protein of 3C-like proteinase nsp5 and nsp8-nsp9 (C8) cut site, PENTAETHYLENE GLYCOL (3 entities in total)
• 機能のキーワード: viral protease, sars-cov-2, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 135444.56

構造登録者

Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Paetzel, M.,Strynadka, N.C.J. (登録日: 2022-07-21, 公開日: 2022-09-21, 最終更新日: 2023-10-18)

• 主引用文献: Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Gentile, F.,Ton, A.T.,Ng, M.,Cherkasov, A.,Strynadka, N.C.J.,Paetzel, M.; X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.; Nat Commun, 13:5196-5196, 2022; PubMed: 36057636; DOI: 10.1038/s41467-022-32854-4

実験手法

X-RAY DIFFRACTION (2.4 Å)