8DOC

Crystal structure of RPE65 in complex with compound 16e and palmitate

8DOC の概要

• エントリーDOI: 10.2210/pdb8doc/pdb
• 分子名称: Retinoid isomerohydrolase, FE (II) ION, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... (6 entities in total)
• 機能のキーワード: 7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, inhibitor, complex, hydrolase
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61746.03

構造登録者

Bassetto, M.,Kiser, P.D. (登録日: 2022-07-12, 公開日: 2023-05-24, 最終更新日: 2023-12-13)

• 主引用文献: Bassetto, M.,Zaluski, J.,Li, B.,Zhang, J.,Badiee, M.,Kiser, P.D.,Tochtrop, G.P.; Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.; J.Med.Chem., 66:8140-8158, 2023; PubMed: 37279401; DOI: 10.1021/acs.jmedchem.3c00461

実験手法

X-RAY DIFFRACTION (2.1 Å)