8DNY
Cryo-EM structure of the human Sec61 complex inhibited by decatransin
Summary for 8DNY
Entry DOI | 10.2210/pdb8dny/pdb |
EMDB information | 27584 |
Descriptor | Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit gamma, Protein transport protein Sec61 subunit beta, ... (4 entities in total) |
Functional Keywords | translocon, decatransin, inhibitor, protein translocation, protein transport, protein transport-inhibitor complex, protein transport/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 71144.83 |
Authors | Park, E.,Itskanov, S. (deposition date: 2022-07-12, release date: 2023-05-24, Last modification date: 2023-11-15) |
Primary citation | Itskanov, S.,Wang, L.,Junne, T.,Sherriff, R.,Xiao, L.,Blanchard, N.,Shi, W.Q.,Forsyth, C.,Hoepfner, D.,Spiess, M.,Park, E. A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19:1063-1071, 2023 Cited by PubMed: 37169959DOI: 10.1038/s41589-023-01337-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.85 Å) |
Structure validation
Download full validation report