8DKV
PPARg bound to JTP-426467 and Co-R peptide
Summary for 8DKV
Entry DOI | 10.2210/pdb8dkv/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 1, 2-chloro-N-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-5-nitrobenzamide, ... (6 entities in total) |
Functional Keywords | pparg, inverse agonist, covalent, jtp-426467, nuclear protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 33672.57 |
Authors | Larsen, N.A. (deposition date: 2022-07-06, release date: 2022-09-07, Last modification date: 2023-10-25) |
Primary citation | Irwin, S.,Karr, C.,Furman, C.,Tsai, J.,Gee, P.,Banka, D.,Wibowo, A.S.,Dementiev, A.A.,O'Shea, M.,Yang, J.,Lowe, J.,Mitchell, L.,Ruppel, S.,Fekkes, P.,Zhu, P.,Korpal, M.,Larsen, N.A. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298:102539-102539, 2022 Cited by PubMed: 36179791DOI: 10.1016/j.jbc.2022.102539 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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