8DKJ

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates

8DKJ の概要

• エントリーDOI: 10.2210/pdb8dkj/pdb
• 分子名称: 3C-like proteinase nsp5 (2 entities in total)
• 機能のキーワード: viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33853.56

構造登録者

Lu, J.,Khan, M.B.,Young, H.S.,Lemieux, M.J. (登録日: 2022-07-05, 公開日: 2023-05-03, 最終更新日: 2024-05-01)

• 主引用文献: Chen, S.A.,Arutyunova, E.,Lu, J.,Khan, M.B.,Rut, W.,Zmudzinski, M.,Shahbaz, S.,Iyyathurai, J.,Moussa, E.W.,Turner, Z.,Bai, B.,Lamer, T.,Nieman, J.A.,Vederas, J.C.,Julien, O.,Drag, M.,Elahi, S.,Young, H.S.,Lemieux, M.J.; SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals.; Acs Cent.Sci., 9:696-708, 2023; PubMed: 37122453; DOI: 10.1021/acscentsci.3c00054

実験手法

X-RAY DIFFRACTION (2.11 Å)