8DKG
Structure of PYCR1 Thr171Met variant complexed with NADH
Summary for 8DKG
Entry DOI | 10.2210/pdb8dkg/pdb |
Descriptor | Isoform 3 of Pyrroline-5-carboxylate reductase 1, mitochondrial, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | amino-acid biosynthesis, oxidoreductase, proline biosynthesis |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 5 |
Total formula weight | 174461.94 |
Authors | Meeks, K.R.,Tanner, J.J. (deposition date: 2022-07-05, release date: 2023-02-08, Last modification date: 2023-10-25) |
Primary citation | Daudu, O.I.,Meeks, K.R.,Zhang, L.,Seravalli, J.,Tanner, J.J.,Becker, D.F. Functional Impact of a Cancer-Related Variant in Human Delta 1 -Pyrroline-5-Carboxylate Reductase 1. Acs Omega, 8:3509-3519, 2023 Cited by PubMed: 36713721DOI: 10.1021/acsomega.2c07788 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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