8DHN

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one

Summary for 8DHN

Entry DOI	10.2210/pdb8dhn/pdb
Related	7V04 8CTF 8DAL 8DDB 8DDE
Descriptor	PA endonuclease, (2P)-6-bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	drug discovery, metal-binding pharmacophore, isosteres, influenza endonuclease, viral protein-inhibitor complex, antiviral protein, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Influenza A virus
Total number of polymer chains	1
Total formula weight	22806.48
Authors	Kohlbrand, A.J.,Stokes, R.W.,Karges, J.,Seo, H.,Sankaran, B.,Cohen, S.M. (deposition date: 2022-06-27, release date: 2022-12-21, Last modification date: 2023-10-25)
Primary citation	Stokes, R.W.,Kohlbrand, A.J.,Seo, H.,Sankaran, B.,Karges, J.,Cohen, S.M. Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14:75-82, 2023 Cited by PubMed: 36655124 DOI: 10.1021/acsmedchemlett.2c00434 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation