8DHN

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one

8DHN の概要

• エントリーDOI: 10.2210/pdb8dhn/pdb
• 関連するPDBエントリー: 7V04 8CTF 8DAL 8DDB 8DDE
• 分子名称: PA endonuclease, (2P)-6-bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one, MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: drug discovery, metal-binding pharmacophore, isosteres, influenza endonuclease, viral protein-inhibitor complex, antiviral protein, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22806.48

構造登録者

Kohlbrand, A.J.,Stokes, R.W.,Karges, J.,Seo, H.,Sankaran, B.,Cohen, S.M. (登録日: 2022-06-27, 公開日: 2022-12-21, 最終更新日: 2023-10-25)

• 主引用文献: Stokes, R.W.,Kohlbrand, A.J.,Seo, H.,Sankaran, B.,Karges, J.,Cohen, S.M.; Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.; Acs Med.Chem.Lett., 14:75-82, 2023; PubMed: 36655124; DOI: 10.1021/acsmedchemlett.2c00434

実験手法

X-RAY DIFFRACTION (2.4 Å)