8DHM
Human TMEM175 in complex with 4-aminopyridine
Summary for 8DHM
| Entry DOI | 10.2210/pdb8dhm/pdb |
| EMDB information | 27436 |
| Descriptor | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION, 4-AMINOPYRIDINE, ... (4 entities in total) |
| Functional Keywords | potassium channel, ion channel, transport protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 111585.95 |
| Authors | Oh, S.,Hite, R.K. (deposition date: 2022-06-27, release date: 2022-11-23, Last modification date: 2024-06-12) |
| Primary citation | Oh, S.,Stix, R.,Zhou, W.,Faraldo-Gomez, J.D.,Hite, R.K. Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175. Proc.Natl.Acad.Sci.USA, 119:e2208882119-e2208882119, 2022 Cited by PubMed: 36279431DOI: 10.1073/pnas.2208882119 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.73 Å) |
Structure validation
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