8DHF
DHODH IN COMPLEX WITH LIGAND 11
Summary for 8DHF
Entry DOI | 10.2210/pdb8dhf/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total) |
Functional Keywords | dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42572.17 |
Authors | Shaffer, P.L. (deposition date: 2022-06-27, release date: 2022-08-17, Last modification date: 2023-10-18) |
Primary citation | Cisar, J.S.,Pietsch, C.,DeRatt, L.G.,Jacoby, E.,Kazmi, F.,Keohane, C.,Legenski, K.,Matico, R.,Shaffer, P.,Simonnet, Y.,Tanner, A.,Wang, C.Y.,Wang, W.,Attar, R.,Edwards, J.P.,Kuduk, S.D. N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia. J.Med.Chem., 65:11241-11256, 2022 Cited by PubMed: 35925768DOI: 10.1021/acs.jmedchem.2c00788 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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