8DGU
Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC25.106 isolated from a vaccinated COVID-19 convalescent
Summary for 8DGU
Entry DOI | 10.2210/pdb8dgu/pdb |
Descriptor | Spike protein S2', Antibody CC25.106 Fab heavy chain, Antibody CC25.106 Fab light chain, ... (5 entities in total) |
Functional Keywords | broadly neutralizing antibody, pan-betacoronavirus, s2 stem helix, spike, sars-cov-2, mers-cov, hcov-hku1, sarbecovirus, cross-reactive, cross-neutralizing, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 49473.12 |
Authors | Liu, H.,Wilson, I.A. (deposition date: 2022-06-24, release date: 2023-01-25, Last modification date: 2023-10-25) |
Primary citation | Zhou, P.,Song, G.,Liu, H.,Yuan, M.,He, W.T.,Beutler, N.,Zhu, X.,Tse, L.V.,Martinez, D.R.,Schafer, A.,Anzanello, F.,Yong, P.,Peng, L.,Dueker, K.,Musharrafieh, R.,Callaghan, S.,Capozzola, T.,Limbo, O.,Parren, M.,Garcia, E.,Rawlings, S.A.,Smith, D.M.,Nemazee, D.,Jardine, J.G.,Safonova, Y.,Briney, B.,Rogers, T.F.,Wilson, I.A.,Baric, R.S.,Gralinski, L.E.,Burton, D.R.,Andrabi, R. Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. Immunity, 56:669-686.e7, 2023 Cited by PubMed: 36889306DOI: 10.1016/j.immuni.2023.02.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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