8DGG

Structure of glycosylated LAG-3 homodimer

8DGG の概要

• エントリーDOI: 10.2210/pdb8dgg/pdb
• 分子名称: Lymphocyte activation gene 3 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: immune checkpoint receptor, homodimer, glycosylation, immune system
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95147.97

構造登録者

Silberstein, J.L.,Mathews, I.I.,Frank, J.A.,Chan, K.-W.,Fernandez, D.,Du, J.,Wang, J.,Kong, X.-P.,Cochran, J.R. (登録日: 2022-06-23, 公開日: 2022-08-17, 最終更新日: 2024-08-07)

• 主引用文献: Silberstein, J.L.,Du, J.,Chan, K.W.,Frank, J.A.,Mathews, I.I.,Kim, Y.B.,You, J.,Lu, Q.,Liu, J.,Philips, E.A.,Liu, P.,Rao, E.,Fernandez, D.,Rodriguez, G.E.,Kong, X.P.,Wang, J.,Cochran, J.R.; Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.; Proc.Natl.Acad.Sci.USA, 121:e2310866121-e2310866121, 2024; PubMed: 38483996; DOI: 10.1073/pnas.2310866121

実験手法

X-RAY DIFFRACTION (3.78 Å)