8DD6

SARS-CoV-2 Main Protease (Mpro) H163A Mutant in Complex with GC376

8DD6 の概要

• エントリーDOI: 10.2210/pdb8dd6/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002495
• 分子名称: ORF1a polyprotein, DIMETHYL SULFOXIDE, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (4 entities in total)
• 機能のキーワード: cysteine protease, sars-cov-2, 3cl-like, gc376, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34322.16

構造登録者

Tran, N.,McLeod, M.J.,Kalyaanamoorthy, S.,Ganesan, A.,Holyoak, T. (登録日: 2022-06-17, 公開日: 2023-09-27)

• 主引用文献: Tran, N.,Dasari, S.,Barwell, S.A.E.,McLeod, M.J.,Kalyaanamoorthy, S.,Holyoak, T.,Ganesan, A.; The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease.; Nat Commun, 14:5625-5625, 2023; PubMed: 37699927; DOI: 10.1038/s41467-023-40023-4

実験手法

X-RAY DIFFRACTION (2.3 Å)