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8DC5

CCHFV GP38 Hoti/Kosovo

8DC5 の概要
エントリーDOI10.2210/pdb8dc5/pdb
分子名称Envelopment polyprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, ... (4 entities in total)
機能のキーワードcrimean-congo hemorrhagic fever, cchfv, glycoprotein, gp38, hoti, kosovo, viral protein
由来する生物種Crimean-Congo hemorrhagic fever orthonairovirus
タンパク質・核酸の鎖数2
化学式量合計63529.82
構造登録者
Durie, I.A.,Bergeron, E.,Pegan, S.D.,McGuire, J. (登録日: 2022-06-15, 公開日: 2022-12-14, 最終更新日: 2024-11-06)
主引用文献Durie, I.A.,Tehrani, Z.R.,Karaaslan, E.,Sorvillo, T.E.,McGuire, J.,Golden, J.W.,Welch, S.R.,Kainulainen, M.H.,Harmon, J.R.,Mousa, J.J.,Gonzalez, D.,Enos, S.,Koksal, I.,Yilmaz, G.,Karakoc, H.N.,Hamidi, S.,Albay, C.,Spengler, J.R.,Spiropoulou, C.F.,Garrison, A.R.,Sajadi, M.M.,Bergeron, E.,Pegan, S.D.
Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus.
Nat Commun, 13:7298-7298, 2022
Cited by
PubMed Abstract: Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes a life-threatening disease with up to a 40% mortality rate. With no approved medical countermeasures, CCHFV is considered a public health priority agent. The non-neutralizing mouse monoclonal antibody (mAb) 13G8 targets CCHFV glycoprotein GP38 and protects mice from lethal CCHFV challenge when administered prophylactically or therapeutically. Here, we reveal the structures of GP38 bound with a human chimeric 13G8 mAb and a newly isolated CC5-17 mAb from a human survivor. These mAbs bind overlapping epitopes with a shifted angle. The broad-spectrum potential of c13G8 and CC5-17 and the practicality of using them against Aigai virus, a closely related nairovirus were examined. Binding studies demonstrate that the presence of non-conserved amino acids in Aigai virus corresponding region prevent CCHFV mAbs from binding Aigai virus GP38. This information, coupled with in vivo efficacy, paves the way for future mAb therapeutics effective against a wide swath of CCHFV strains.
PubMed: 36435827
DOI: 10.1038/s41467-022-34923-0
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.21 Å)
構造検証レポート
Validation report summary of 8dc5
検証レポート(詳細版)ダウンロードをダウンロード

238582

件を2025-07-09に公開中

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