8D9L

CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA and SAM

Summary for 8D9L

• Entry DOI: 10.2210/pdb8d9l/pdb
• EMDB information: 27265
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, tRNA (guanine-N(7)-)-methyltransferase, Lys-tRNA, ... (4 entities in total)
• Functional Keywords: cancer protein, methyl transferase, transferase, transferase-rna complex, transferase/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 100501.38

Authors

Ruiz-Arroyo, V.M.,Nam, Y. (deposition date: 2022-06-10, release date: 2023-01-11, Last modification date: 2024-06-12)

• Primary citation: Ruiz-Arroyo, V.M.,Raj, R.,Babu, K.,Onolbaatar, O.,Roberts, P.H.,Nam, Y.; Structures and mechanisms of tRNA methylation by METTL1-WDR4.; Nature, 613:383-390, 2023; PubMed: 36599982; DOI: 10.1038/s41586-022-05565-5

Experimental method

ELECTRON MICROSCOPY (4.04 Å)