8D9K

CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA

Summary for 8D9K

• Entry DOI: 10.2210/pdb8d9k/pdb
• EMDB information: 27264
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, RNA (65-MER) (3 entities in total)
• Functional Keywords: cancer protein, methyl transferase, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 99801.74

Authors

Ruiz-Arroyo, V.M.,Nam, Y. (deposition date: 2022-06-10, release date: 2023-01-11, Last modification date: 2024-06-12)

• Primary citation: Ruiz-Arroyo, V.M.,Raj, R.,Babu, K.,Onolbaatar, O.,Roberts, P.H.,Nam, Y.; Structures and mechanisms of tRNA methylation by METTL1-WDR4.; Nature, 613:383-390, 2023; PubMed: 36599982; DOI: 10.1038/s41586-022-05565-5

Experimental method

ELECTRON MICROSCOPY (3.72 Å)