8D7Z
Cereblon-DDB1 bound to CC-92480 and Ikaros ZF1-2-3
Summary for 8D7Z
Entry DOI | 10.2210/pdb8d7z/pdb |
EMDB information | 27234 27235 27236 27237 27238 27239 27240 27241 27242 |
Descriptor | DNA damage-binding protein 1, Protein cereblon, DNA-binding protein Ikaros, ... (5 entities in total) |
Functional Keywords | ubiquitin, crl4, adaptor, cereblon, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 188131.00 |
Authors | Watson, E.R.,Lander, G.C. (deposition date: 2022-06-07, release date: 2022-07-20, Last modification date: 2024-06-12) |
Primary citation | Watson, E.R.,Novick, S.,Matyskiela, M.E.,Chamberlain, P.P.,H de la Pena, A.,Zhu, J.,Tran, E.,Griffin, P.R.,Wertz, I.E.,Lander, G.C. Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378:549-553, 2022 Cited by PubMed: 36378961DOI: 10.1126/science.add7574 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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