8D73

Crystal Structure of EGFR LRTM with compound 7

8D73 の概要

• エントリーDOI: 10.2210/pdb8d73/pdb
• 分子名称: Epidermal growth factor receptor, GLYCEROL, (3S,4R)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol, ... (4 entities in total)
• 機能のキーワード: protein kinase, inhibitor, kinase domain, mutation, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80604.67

構造登録者

Kim, J.L. (登録日: 2022-06-07, 公開日: 2022-07-27, 最終更新日: 2023-10-18)

• 主引用文献: Eno, M.S.,Brubaker, J.D.,Campbell, J.E.,De Savi, C.,Guzi, T.J.,Williams, B.D.,Wilson, D.,Wilson, K.,Brooijmans, N.,Kim, J.,Ozen, A.,Perola, E.,Hsieh, J.,Brown, V.,Fetalvero, K.,Garner, A.,Zhang, Z.,Stevison, F.,Woessner, R.,Singh, J.,Timsit, Y.,Kinkema, C.,Medendorp, C.,Lee, C.,Albayya, F.,Zalutskaya, A.,Schalm, S.,Dineen, T.A.; Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.; J.Med.Chem., 65:9662-9677, 2022; PubMed: 35838760; DOI: 10.1021/acs.jmedchem.2c00704

実験手法

X-RAY DIFFRACTION (2.17 Å)