8D6E

Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306

8D6E の概要

• エントリーDOI: 10.2210/pdb8d6e/pdb
• 分子名称: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION, (1P)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, ... (6 entities in total)
• 機能のキーワード: kinase inhibitor complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70858.24

構造登録者

Pau, V.P.T.,Mao, D.Y.L.,Mader, P.,Orlicky, S.,Sicheri, F. (登録日: 2022-06-06, 公開日: 2022-07-27, 最終更新日: 2023-10-18)

• 主引用文献: Szychowski, J.,Papp, R.,Dietrich, E.,Liu, B.,Vallee, F.,Leclaire, M.E.,Fourtounis, J.,Martino, G.,Perryman, A.L.,Pau, V.,Yin, S.Y.,Mader, P.,Roulston, A.,Truchon, J.F.,Marshall, C.G.,Diallo, M.,Duffy, N.M.,Stocco, R.,Godbout, C.,Bonneau-Fortin, A.,Kryczka, R.,Bhaskaran, V.,Mao, D.,Orlicky, S.,Beaulieu, P.,Turcotte, P.,Kurinov, I.,Sicheri, F.,Mamane, Y.,Gallant, M.,Black, W.C.; Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.; J.Med.Chem., 65:10251-10284, 2022; PubMed: 35880755; DOI: 10.1021/acs.jmedchem.2c00552

実験手法

X-RAY DIFFRACTION (2.15 Å)