8D4U

Crystal Structure of Neutrophil Elastase Inhibited by Eap2 from S. aureus

Summary for 8D4U

Entry DOI	10.2210/pdb8d4u/pdb
Related	8D4Q 8D4S
Descriptor	Neutrophil elastase, Extracellular Adherence Protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	protease inhibitor, immune evasion, neutrophil, s. aureus, protein binding, hydrolase-inhibitor, protein binding complex, hydrolase/inhibitor
Biological source	Staphylococcus aureus subsp. aureus More
Total number of polymer chains	4
Total formula weight	70047.09
Authors	Gido, C.D.,Herdendorf, T.J.,Geisbrecht, B.V. (deposition date: 2022-06-02, release date: 2022-12-21, Last modification date: 2023-10-25)
Primary citation	Gido, C.D.,Herdendorf, T.J.,Geisbrecht, B.V. Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299:102969-102969, 2023 Cited by PubMed: 36736422 DOI: 10.1016/j.jbc.2023.102969 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation