8CXR

Crystal structure of MraY bound to a sphaerimicin analogue

8CXR の概要

• エントリーDOI: 10.2210/pdb8cxr/pdb
• 分子名称: MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (1S,4R,5S,6R,7S,9S,10S,11S,13S,14R)-9-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]-14-(hexadecanoyloxy)-5,6,13-trihydroxy-8,16-dioxa-2,11-diazatricyclo[9.3.1.1~4,7~]hexadecane-10-carboxylic acid (3 entities in total)
• 機能のキーワード: mray, nanobody, sphaerimicin, membrane protein, membrane protein-transferase complex, membrane protein/transferase
• 由来する生物種: Lama glama; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 225619.12

構造登録者

Mashalidis, E.H.,Lee, S.Y. (登録日: 2022-05-22, 公開日: 2023-03-29, 最終更新日: 2023-10-25)

• 主引用文献: Nakaya, T.,Yabe, M.,Mashalidis, E.H.,Sato, T.,Yamamoto, K.,Hikiji, Y.,Katsuyama, A.,Shinohara, M.,Minato, Y.,Takahashi, S.,Horiuchi, M.,Yokota, S.I.,Lee, S.Y.,Ichikawa, S.; Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY.; Nat Commun, 13:7575-7575, 2022; PubMed: 36539416; DOI: 10.1038/s41467-022-35227-z

実験手法

X-RAY DIFFRACTION (3.65 Å)