8CXL

Structure of NapH3, a vanadium-dependent haloperoxidase homolog catalyzing the stereospecific alpha-hydroxyketone rearrangement reaction in napyradiomycin biosynthesis

8CXL の概要

• エントリーDOI: 10.2210/pdb8cxl/pdb
• 関連するPDBエントリー: 3w35 3w36
• 分子名称: NapH3, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: vanadium-dependent haloperoxidase, vhpo, alpha-hydroxyketone rearrangement, napyradiomycin, biosynthetic protein
• 由来する生物種: Streptomyces sp. CNQ-525
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103610.02

構造登録者

Chen, P.Y.-T.,Chekan, J.R.,Moore, B.S. (登録日: 2022-05-21, 公開日: 2022-08-31, 最終更新日: 2023-10-18)

• 主引用文献: Chen, P.Y.,Adak, S.,Chekan, J.R.,Liscombe, D.K.,Miyanaga, A.,Bernhardt, P.,Diethelm, S.,Fielding, E.N.,George, J.H.,Miles, Z.D.,Murray, L.A.M.,Steele, T.S.,Winter, J.M.,Noel, J.P.,Moore, B.S.; Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis.; Biochemistry, 61:1844-1852, 2022; PubMed: 35985031; DOI: 10.1021/acs.biochem.2c00338

実験手法

X-RAY DIFFRACTION (1.98 Å)