8CUR
Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid
Summary for 8CUR
Entry DOI | 10.2210/pdb8cur/pdb |
Descriptor | Cyclin-dependent kinase 2, 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid (3 entities in total) |
Functional Keywords | cell cycle, protein-inhibitor complex, kinase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34507.44 |
Authors | Tripathi, S.M.,Tambo, C.S.,Kiss, G.,Rubin, S.M. (deposition date: 2022-05-17, release date: 2023-04-05, Last modification date: 2023-10-25) |
Primary citation | Tambo, C.S.,Tripathi, S.,Perera, B.G.K.,Maly, D.J.,Bridges, A.J.,Kiss, G.,Rubin, S.M. Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics. Acs Chem.Biol., 18:431-440, 2023 Cited by PubMed: 36724382DOI: 10.1021/acschembio.3c00015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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