8CUR

Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid

8CUR の概要

• エントリーDOI: 10.2210/pdb8cur/pdb
• 分子名称: Cyclin-dependent kinase 2, 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid (3 entities in total)
• 機能のキーワード: cell cycle, protein-inhibitor complex, kinase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34507.44

構造登録者

Tripathi, S.M.,Tambo, C.S.,Kiss, G.,Rubin, S.M. (登録日: 2022-05-17, 公開日: 2023-04-05, 最終更新日: 2023-10-25)

• 主引用文献: Tambo, C.S.,Tripathi, S.,Perera, B.G.K.,Maly, D.J.,Bridges, A.J.,Kiss, G.,Rubin, S.M.; Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics.; Acs Chem.Biol., 18:431-440, 2023; PubMed: 36724382; DOI: 10.1021/acschembio.3c00015

実験手法

X-RAY DIFFRACTION (2.2 Å)