8CUQ

X-ray crystal structure of ADC-33 in complex with sulfonamidoboronic acid 6e

8CUQ の概要

• エントリーDOI: 10.2210/pdb8cuq/pdb
• 分子名称: Beta-lactamase, 3-[(4R)-4-ethyl-5,7,7-trihydroxy-2,2,7-trioxo-6-oxa-2lambda~6~-thia-3-aza-7lambda~5~-phospha-5-boraheptan-1-yl]benzoic acid (3 entities in total)
• 機能のキーワード: cephalasporinase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82391.31

構造登録者

Fernando, M.C.,Wallar, B.J.,Powers, R.A. (登録日: 2022-05-17, 公開日: 2023-04-05, 最終更新日: 2024-05-01)

• 主引用文献: Introvigne, M.L.,Beardsley, T.J.,Fernando, M.C.,Leonard, D.A.,Wallar, B.J.,Rudin, S.D.,Taracila, M.A.,Rather, P.N.,Colquhoun, J.M.,Song, S.,Fini, F.,Hujer, K.M.,Hujer, A.M.,Prati, F.,Powers, R.A.,Bonomo, R.A.,Caselli, E.; Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii .; Antibiotics, 12:-, 2023; PubMed: 37107006; DOI: 10.3390/antibiotics12040644

実験手法

X-RAY DIFFRACTION (1.55 Å)