8CTI

Cryo-EM structure of human METTL1-WDR4-tRNA(Val) complex

Summary for 8CTI

Entry DOI	10.2210/pdb8cti/pdb
EMDB information	26991
Descriptor	tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, tRNA-Val-TAC-2-1 (3 entities in total)
Functional Keywords	epitranscriptome, m7g, mettl1, methylation, methyltransferase, transferase, transferase-rna complex, transferase/rna
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	102331.42
Authors	Li, J.,Wang, L.,Fontana, P.,Hunkeler, M.,Roy-Burman, S.S.,Wu, H.,Fischer, E.S.,Gregory, R.I. (deposition date: 2022-05-14, release date: 2022-12-07, Last modification date: 2024-06-12)
Primary citation	Li, J.,Wang, L.,Hahn, Q.,Nowak, R.P.,Viennet, T.,Orellana, E.A.,Roy Burman, S.S.,Yue, H.,Hunkeler, M.,Fontana, P.,Wu, H.,Arthanari, H.,Fischer, E.S.,Gregory, R.I. Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature, 613:391-397, 2023 Cited by PubMed: 36599985 DOI: 10.1038/s41586-022-05566-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation