8CRK

Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 7H2 refined against anomalous diffraction data

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8CRK の概要

• エントリーDOI: 10.2210/pdb8crk/pdb
• 分子名称: Host translation inhibitor nsp1, (1~{R})-1-(4-chlorophenyl)ethanamine (3 entities in total)
• 機能のキーワード: sars-cov-2, non-structural protein 1, fragment hit, anomalous diffraction, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13264.78

構造登録者

Ma, S.,Mikhailik, V.,Pinotsis, N.,Bowler, M.W.,Kozielski, F. (登録日: 2023-03-08, 公開日: 2023-10-04)

• 主引用文献: Ma, S.,Mykhaylyk, V.,Bowler, M.W.,Pinotsis, N.,Kozielski, F.; High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1.; Int J Mol Sci, 24:-, 2023; PubMed: 37446375; DOI: 10.3390/ijms241311197

実験手法

X-RAY DIFFRACTION (1.1 Å)