8CRH
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil
Summary for 8CRH
| Entry DOI | 10.2210/pdb8crh/pdb |
| Descriptor | Dihydrofolate reductase, 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | dihydrofolate reductase candida auris nadph cycloguanil, hydrolase |
| Biological source | [Candida] auris |
| Total number of polymer chains | 2 |
| Total formula weight | 51081.30 |
| Authors | Kirkman, T.J.,Dias, M.V.B. (deposition date: 2023-03-08, release date: 2023-08-02, Last modification date: 2023-08-09) |
| Primary citation | Kirkman, T.,Sketcher, A.,de Morais Barroso, V.,Ishida, K.,Tosin, M.,Dias, M.V.B. Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. Acta Crystallogr D Struct Biol, 79:735-745, 2023 Cited by PubMed: 37428844DOI: 10.1107/S2059798323004709 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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