8CRH

Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil

8CRH の概要

• エントリーDOI: 10.2210/pdb8crh/pdb
• 分子名称: Dihydrofolate reductase, 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase candida auris nadph cycloguanil, hydrolase
• 由来する生物種: [Candida] auris
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51081.30

構造登録者

Kirkman, T.J.,Dias, M.V.B. (登録日: 2023-03-08, 公開日: 2023-08-02, 最終更新日: 2023-08-09)

• 主引用文献: Kirkman, T.,Sketcher, A.,de Morais Barroso, V.,Ishida, K.,Tosin, M.,Dias, M.V.B.; Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris.; Acta Crystallogr D Struct Biol, 79:735-745, 2023; PubMed: 37428844; DOI: 10.1107/S2059798323004709

実験手法

X-RAY DIFFRACTION (1.3 Å)