8CQL

pVHL:EloB:EloC in complex with (2S,4R)-N-((S)-1-(5-Fluoro-2-methoxy-4-(4-methylthiazol-5-yl)phenyl)ethyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide (Compound 33)

8CQL の概要

• エントリーDOI: 10.2210/pdb8cql/pdb
• 分子名称: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
• 機能のキーワード: inhibitor, e3 ligase complex, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 169263.73

構造登録者

Casement, R.,Phuong Vu, L.,Ciulli, A.,Gutschow, M. (登録日: 2023-03-06, 公開日: 2023-09-27, 最終更新日: 2023-10-11)

• 主引用文献: Vu, L.P.,Diehl, C.J.,Casement, R.,Bond, A.G.,Steinebach, C.,Strasek, N.,Bricelj, A.,Perdih, A.,Schnakenburg, G.,Sosic, I.,Ciulli, A.,Gutschow, M.; Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers.; J.Med.Chem., 66:12776-12811, 2023; PubMed: 37708384; DOI: 10.1021/acs.jmedchem.3c00434

実験手法

X-RAY DIFFRACTION (2.38 Å)