8CQI

Human heparanase in complex with inhibitor R3794

Summary for 8CQI

• Entry DOI: 10.2210/pdb8cqi/pdb
• Descriptor: Heparanase 50 kDa subunit, Heparanase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: hydrolase, glycoside hydrolase, protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 53923.91

Authors

Moran, E.M.,Davies, G.J.,Chen, C.,Nieuwendijk, E.V.,Wu, L.,Skoulikopoulou, F.,Riet, V.V.,Overkleeft, H.S.,Armstrong, Z. (deposition date: 2023-03-06, release date: 2024-01-10, Last modification date: 2024-01-24)

• Primary citation: Chen, Y.,van den Nieuwendijk, A.M.C.H.,Wu, L.,Moran, E.,Skoulikopoulou, F.,van Riet, V.,Overkleeft, H.S.,Davies, G.J.,Armstrong, Z.; Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B.; J.Am.Chem.Soc., 146:125-133, 2024; PubMed: 38118176; DOI: 10.1021/jacs.3c04162

Experimental method

X-RAY DIFFRACTION (2.1 Å)