8CQE
pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(2-methyl-4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (Compound 37)
Summary for 8CQE
Entry DOI | 10.2210/pdb8cqe/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total) |
Functional Keywords | inhibitor, e3 ligase complex, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 169247.77 |
Authors | Casement, R.,Phuong Vu, L.,Ciulli, A.,Gutschow, M. (deposition date: 2023-03-06, release date: 2023-09-27, Last modification date: 2023-10-11) |
Primary citation | Vu, L.P.,Diehl, C.J.,Casement, R.,Bond, A.G.,Steinebach, C.,Strasek, N.,Bricelj, A.,Perdih, A.,Schnakenburg, G.,Sosic, I.,Ciulli, A.,Gutschow, M. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers. J.Med.Chem., 66:12776-12811, 2023 Cited by PubMed: 37708384DOI: 10.1021/acs.jmedchem.3c00434 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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