8CQA
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide
Summary for 8CQA
Entry DOI | 10.2210/pdb8cqa/pdb |
Descriptor | Dihydrofolate reductase, ~{N}-[4-[2,6-bis(azanyl)-5-(2-cyclopropylethyl)pyrimidin-4-yl]phenyl]ethanamide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
Functional Keywords | dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 38132.94 |
Authors | |
Primary citation | Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently) To Be Published, |
Experimental method |
Structure validation
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