8CQ9
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine
8CQ9 の概要
エントリーDOI | 10.2210/pdb8cq9/pdb |
分子名称 | Dihydrofolate reductase, 5-[(~{E})-2-cyclopropylethenyl]-6-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
機能のキーワード | dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein |
由来する生物種 | Mycobacterium tuberculosis |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 38615.41 |
構造登録者 | |
主引用文献 | Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently) To Be Published, |
実験手法 | X-RAY DIFFRACTION (1.75 Å) |
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