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8CQ9

Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine

8CQ9 の概要
エントリーDOI10.2210/pdb8cq9/pdb
分子名称Dihydrofolate reductase, 5-[(~{E})-2-cyclopropylethenyl]-6-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
機能のキーワードdihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein
由来する生物種Mycobacterium tuberculosis
タンパク質・核酸の鎖数2
化学式量合計38615.41
構造登録者
Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. (登録日: 2023-03-04, 公開日: 2024-03-13)
主引用文献Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G.
Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently)
To Be Published,
実験手法
X-RAY DIFFRACTION (1.75 Å)
構造検証レポート
Validation report summary of 8cq9
検証レポート(詳細版)ダウンロードをダウンロード

222926

件を2024-07-24に公開中

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