8CQ8
Mycobacterium tuberculosis dihydrofolate reductase in complex with methyl 4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)benzoate
Summary for 8CQ8
Entry DOI | 10.2210/pdb8cq8/pdb |
Descriptor | Dihydrofolate reductase, methyl 4-[2,6-bis(azanyl)-5-(2-cyclopropylethynyl)pyrimidin-4-yl]benzoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total) |
Functional Keywords | dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 38981.93 |
Authors | |
Primary citation | Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently) To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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