8CQ8

Mycobacterium tuberculosis dihydrofolate reductase in complex with methyl 4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)benzoate

8CQ8 の概要

• エントリーDOI: 10.2210/pdb8cq8/pdb
• 分子名称: Dihydrofolate reductase, methyl 4-[2,6-bis(azanyl)-5-(2-cyclopropylethynyl)pyrimidin-4-yl]benzoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38981.93

構造登録者

Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. (登録日: 2023-03-04, 公開日: 2024-03-13)

• 主引用文献: Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G.; Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently); To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)