8COV

Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid

Summary for 8COV

Entry DOI	10.2210/pdb8cov/pdb
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, ... (6 entities in total)
Functional Keywords	fabf, pseudomonas aeruginosa, inhibitor, complex, transferase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	89290.50
Authors	Georgiou, C.,Brenk, R.,Espeland, L.O. (deposition date: 2023-02-28, release date: 2024-01-10)
Primary citation	Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R. New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023 Cited by DOI: 10.26434/chemrxiv-2023-cwk25 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation