8CO3

Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide

Summary for 8CO3

Entry DOI	10.2210/pdb8co3/pdb
Descriptor	Carbonic anhydrase 12, ZINC ION, 5-(5-methyl-6-quinolin-5-yl-pyridin-3-yl)thiophene-2-sulfonamide, ... (4 entities in total)
Functional Keywords	ca xii, ca 12, carbonic anhydrase xii, carbonic anhydrase 12, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	121216.32
Authors	Leitans, J.,Dvinskis, E.,Tars, K. (deposition date: 2023-02-26, release date: 2023-12-13)
Primary citation	Ivanova, J.N.,Nocentini, A.,Ta Rs, K.,Leita Ns, J.N.,Dvinskis, E.,Kazaks, A.,Domraceva, I.,Supuran, C.T.,Zalubovskis, R. Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. J.Med.Chem., 66:5703-5718, 2023 Cited by PubMed: 37022308 DOI: 10.1021/acs.jmedchem.3c00007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation