8CO3

Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide

8CO3 の概要

• エントリーDOI: 10.2210/pdb8co3/pdb
• 分子名称: Carbonic anhydrase 12, ZINC ION, 5-(5-methyl-6-quinolin-5-yl-pyridin-3-yl)thiophene-2-sulfonamide, ... (4 entities in total)
• 機能のキーワード: ca xii, ca 12, carbonic anhydrase xii, carbonic anhydrase 12, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 121216.32

構造登録者

Leitans, J.,Dvinskis, E.,Tars, K. (登録日: 2023-02-26, 公開日: 2023-12-13)

• 主引用文献: Ivanova, J.N.,Nocentini, A.,Ta Rs, K.,Leita Ns, J.N.,Dvinskis, E.,Kazaks, A.,Domraceva, I.,Supuran, C.T.,Zalubovskis, R.; Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect.; J.Med.Chem., 66:5703-5718, 2023; PubMed: 37022308; DOI: 10.1021/acs.jmedchem.3c00007

実験手法

X-RAY DIFFRACTION (1.68 Å)