8CNP

Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)

Summary for 8CNP

• Entry DOI: 10.2210/pdb8cnp/pdb
• Descriptor: Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid, ... (5 entities in total)
• Functional Keywords: human aldose reductase, har, aldo-keto-reductase, mutant l300g, sar_061 ligand, nadp+, diabetes, ligand in transient pocket, no flip, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37125.06

Authors

Klee, L.-S.,Heine, A.,Klebe, G. (deposition date: 2023-02-24, release date: 2024-03-06)

• Primary citation: Klee, L.-S.,Heine, A.,Klebe, G.,Scheer, F.; Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid); To Be Published,

Experimental method

X-RAY DIFFRACTION (0.94 Å)