8CNP

Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)

8CNP の概要

• エントリーDOI: 10.2210/pdb8cnp/pdb
• 分子名称: Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid, ... (5 entities in total)
• 機能のキーワード: human aldose reductase, har, aldo-keto-reductase, mutant l300g, sar_061 ligand, nadp+, diabetes, ligand in transient pocket, no flip, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37125.06

構造登録者

Klee, L.-S.,Heine, A.,Klebe, G. (登録日: 2023-02-24, 公開日: 2024-03-06)

• 主引用文献: Klee, L.-S.,Heine, A.,Klebe, G.,Scheer, F.; Human Aldose Reductase Mutant L300G in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid); To Be Published,

実験手法

X-RAY DIFFRACTION (0.94 Å)