8CML
Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2
Summary for 8CML
Entry DOI | 10.2210/pdb8cml/pdb |
EMDB information | 16730 |
Descriptor | Nanobody UNbC5-2, Complement C5 beta chain, Complement C5 alpha chain, ... (5 entities in total) |
Functional Keywords | nanobody, inhibitor, complement, c5, inhibition, convertase, classical pathway, nanobody-antigen complex, alternative pathway, immune system |
Biological source | Lama glama More |
Total number of polymer chains | 4 |
Total formula weight | 219273.93 |
Authors | |
Primary citation | Struijf, E.M.,De la O Becerra, K.I.,Ruyken, M.,de Haas, C.J.C.,van Oosterom, F.,Siere, D.Y.,van Keulen, J.E.,Heesterbeek, D.A.C.,Dolk, E.,Heukers, R.,Bardoel, B.W.,Gros, P.,Rooijakkers, S.H.M. Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies. J.Biol.Chem., 299:104956-104956, 2023 Cited by PubMed: 37356719DOI: 10.1016/j.jbc.2023.104956 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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