8CML

Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2

8CML の概要

• エントリーDOI: 10.2210/pdb8cml/pdb
• EMDBエントリー: 16730
• 分子名称: Nanobody UNbC5-2, Complement C5 beta chain, Complement C5 alpha chain, ... (5 entities in total)
• 機能のキーワード: nanobody, inhibitor, complement, c5, inhibition, convertase, classical pathway, nanobody-antigen complex, alternative pathway, immune system
• 由来する生物種: Lama glama; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 219273.93

構造登録者

De la O Becerra, K.I.,Gros, P. (登録日: 2023-02-20, 公開日: 2023-09-27)

• 主引用文献: Struijf, E.M.,De la O Becerra, K.I.,Ruyken, M.,de Haas, C.J.C.,van Oosterom, F.,Siere, D.Y.,van Keulen, J.E.,Heesterbeek, D.A.C.,Dolk, E.,Heukers, R.,Bardoel, B.W.,Gros, P.,Rooijakkers, S.H.M.; Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies.; J.Biol.Chem., 299:104956-104956, 2023; PubMed: 37356719; DOI: 10.1016/j.jbc.2023.104956

実験手法

ELECTRON MICROSCOPY (3.6 Å)